Lg. Menon et al., EFFECT OF ISOFLAVONES GENISTEIN AND DAIDZEIN IN THE INHIBITION OF LUNG METASTASIS IN MICE INDUCED BY B16F-10 MELANOMA-CELLS, Nutrition and cancer, 30(1), 1998, pp. 74-77
Two dietary soybean isoflavones, genistein and daidzein, were studied
for the inhibition of lung metastasis induced by B16F-10 melanoma cell
s in C57BL/6 mice. The isoflavone genistein at 200 mu mol/kg body wt s
ignificantly inhibited (53.6%, p < 0.001) lung tumor nodule formation.
The lung collagen hydroxyproline content and the serum sialic acid le
vel, a marker of metastasis, were also significantly lower in these an
imals than in untreated tumor-bearing animals. Genistein treatment als
o increased the life span of the tumor-bearing animals (47.7%, p < 0.0
01). The isoflavone daidzein had no significant effect on the reductio
n of lung metastasis induced by B16F-10 melanoma cells.