The effects of methodology on the results of epidemiologic studies tha
t involve collection of nutritional data, especially those involving l
ong-term-onset illnesses such as cancer, have not yet been carefully e
valuated. We present methodological features of a quantitative dietary
history and physical activity questionnaire and discuss their contrib
ution to the final results. The results of our analysis are as follows
: I) Forty-seven percent of the population consumed >100 food items ye
arly. 2) The mean number of calories contributed by items eaten less t
han once a week exceeded 200 kcal/day in 50% of intewiewees. 3) Sevent
y-six percent of the patients had undergone dietary changes during the
course of adult life. Of the 379 individuals who reported no changes
when asked general questions, 61.8% reported changes when asked specif
ically about each food item in the questionnaire. 4) Physical activity
was significantly correlated with mean daily energy intake (r = 0.208
, p < 0.001). We conclude that certain methodological features of ques
tionnaires, such as extensive listing of food items, precise documenta
tion of food quantity, inquiries about former earing habits, and inclu
sion of questions about physical activity, increase accuracy in evalua
tions of dietary habits. Our analysis provides practical information f
or future planning of nutritional questionnaires.