For 4 decades, vigorous efforts hate been based on the premise that ea
rly intervention for children of poverty and, more recently, for child
ren with developmental disabilities can yield significant improvements
in cognitive, academic, and social outcomes. The history of these eff
orts is briefly summarized and a conceptual framework presented to und
erstand the design, research, and policy relevance of these early inte
rventions. This framework, biosocial developmental contextualism, deri
ves from social ecology developmental systems theory, developmental ep
idemiology and developmental neurobiology. This integrative perspectiv
e predicts that fragmented, weak efforts in early intervention are not
likely to succeed, whereas intensive, high-quality, ecologically perv
asive interventions can and do. Relevant evidence is summarized in 6 p
rinciples about efficacy of early intervention. The public policy chal
lenge in early intervention is to contain costs by more precisely targ
eting early interventions to those who mast need and benefit from thes
e interventions. The empirical evidence on biobehavioral effects of ea
rly experience and early intervention has direct relevance to federal
and stare policy development and resource allocation.