EARLY ASCARIS-SUUM MIGRATION IN MICE AS A MODEL FOR PIGS

A study was made of the early migratory pattern of Ascaris suum in mic e. Mice were each inoculated orally with a single dose of 2,500 infect ive eggs and then killed at 2, 3, 6, 8, 10, and 12 hr postinoculation (PI). At necropsy, it was observed that the larvae had penetrated the mouse cecum and colon and had reached the liver by 4 hr PI. This migra tory behavior closely mimics what is observed in the pig and suggests that the mouse may serve as an experimental model for intestinal immun ity in the early phase of A. suum infection.