MEMBRANE-PERMEABILITY TRANSITION AS INDUCED BY DYSFUNCTION OF THE ELECTRON-TRANSPORT CHAIN

Authors
CHAVEZ E MELENDEZ E ZAZUETA C REYESVIVAS H PERALES SG
Citation
E. Chavez et al., MEMBRANE-PERMEABILITY TRANSITION AS INDUCED BY DYSFUNCTION OF THE ELECTRON-TRANSPORT CHAIN, Biochemistry and molecular biology international, 41(5), 1997, pp. 961-968
Citations number
16
Categorie Soggetti
Biology
Journal title
Biochemistry and molecular biology international → ACNP
ISSN journal
10399712
Volume
41
Issue
5
Year of publication
1997
Pages
961 - 968
Database
ISI
SICI code
1039-9712(1997)41:5<961:MTAIBD>2.0.ZU;2-1
Abstract
The results in this paper indicate that mitochondrial permeability tra nsition is' activated by dysfunction of the respiratory chain caused b y anaerobiosis, exhaustion of the oxidative substrate, and antimycin A , in the presence of 100 mu M Ca2+. Membrane damage coincides with the collapse of the electric gradient. The opening of the non-selective p ore is prevented by cyclosporin A.