INHIBITORY EFFECT OF CHLORPROMAZINE ON NEMATODE EGGS AND LARVAE

Citation
Mr. Patel et Wc. Campbell, INHIBITORY EFFECT OF CHLORPROMAZINE ON NEMATODE EGGS AND LARVAE, The Journal of parasitology, 84(1), 1998, pp. 191-192
Citations number
6
Categorie Soggetti
Parasitiology
Journal title
ISSN journal
00223395
Volume
84
Issue
1
Year of publication
1998
Pages
191 - 192
Database
ISI
SICI code
0022-3395(1998)84:1<191:IEOCON>2.0.ZU;2-E
Abstract
Chlorpromazine inhibited the hatching of eggs of the parasitic nematod e Haemonchus contortus and the free-living nematode Caenorhabditis ele gans. In both species, hatching occurred st a concentration of 100 mu g/ml but was almost totally blocked at 400 mu g/ml. In the case of C. elegans, the effect was shown to be reversible by removal of chlorprom azine after exposure of the eggs to the drug for 1 hr. Caenorhabditis elegans larvae that hatched in a chlorpromazine concentration of 100 m u g/ml were killed, but those that hatched in a concentration of 6.25 mu g/ml were not. Taken together with data published by others, these observations indicate that the first-stage larva of C. elegans is less sensitive to chlorpromazine than is the adult worm.