EVIDENCE FOR ANTIRADICAL AND ANTIOXIDANT PROPERTIES OF 4 BIOLOGICALLY-ACTIVE N,N-DIETHYLAMINOETHYL ETHERS OF FLAVANONE OXIMES - A COMPARISON WITH NATURAL POLYPHENOLIC FLAVONOID (RUTIN) ACTION

The antiradical and antioxidant activities of four biologically active N,N-diethyloaminoethyl ethers of flavanone oximes (N,N-DEAEFo) were i nvestigated in vitro and compared with these of polyphenolic flavonoid (rutin). Four experimental models were used: iron- and ascorbate driv en Fenton systems, gamma-radiolysis, xanthine/xanthine oxidase system and diphenylpicrylhydrazyl (DPPH) radical scavenging. The results clea rly indicate that N,N-DEAEFo are acting as promising antioxidants and radioprotectors comparable to rutin activities: they should prove to b e useful under acute oxidative stress conditions for which both proper ties were required.