Alcohol is the most frequently used psycho-active substance during ado
lescence. Adolescents who misuse or overindulge in alcohol are at risk
for serious social and psychological consequences. Several preventive
approaches can help adolescents deal with peer pressure that contribu
tes to alcohol use experimentation and escalation. One promising appro
ach involves teaching adolescents skills to refuse offers of alcohol a
nd other drugs. Few studies, however, have examined how this approach
works; that is, the connection between the prevention effort, refusal
skills, and drinking behavior. This paper investigates the relationshi
ps among the intervention, refusal skills, and alcohol misuse in the A
lcohol Misuse Prevention Study, a randomized, pre/post experimental st
udy. Based on data from sixth through tenth graders (average N per gra
de = approximately 400), regression analyses indicate that refusal ski
lls are significant mediators of the effect of the intervention on alc
ohol misuse.