K. Alford et al., COMPARISON OF THE INFLAMMATORY RESPONSES OF MICE INFECTED WITH AMERICAN AND AUSTRALIAN TRICHINELLA-PSEUDOSPIRALIS OR TRICHINELLA-SPIRALIS, International journal for parasitology, 28(2), 1998, pp. 343-348
This study was designed to determine if the Tasmanian devil isolate of
Trichinella pseudospiralis suppressed inflammation as does the origin
al isolate. While adult worm numbers were similar in all groups, lower
enteritis occurred in devil isolate-infected mice compared with mice
infected with the original isolate of T, pseudospiralis or with Trichi
nella spiralis. Diaphragm muscle inflammation was greater in T. spiral
is-infected than in mice infected with either isolate of T. pseudospir
alis or concurrently infected with T. spiralis and either of the isola
tes of T. pseudospiralis. Granuloma inflammation was lower in mice inf
ected with either isolate of T. pseudospiralis compared with uninfecte
d or T. spirialis-infected mice. The devil isolate down-regulated infl
ammation more profoundly during the intestinal phase than the muscle p
hase compared to the original isolate, differences which may be relate
d to the biology of their natural hosts. (C) 1998 Australian Society f
or Parasitology. Published by Elsevier Science Ltd.