COMPARISON OF THE INFLAMMATORY RESPONSES OF MICE INFECTED WITH AMERICAN AND AUSTRALIAN TRICHINELLA-PSEUDOSPIRALIS OR TRICHINELLA-SPIRALIS

This study was designed to determine if the Tasmanian devil isolate of Trichinella pseudospiralis suppressed inflammation as does the origin al isolate. While adult worm numbers were similar in all groups, lower enteritis occurred in devil isolate-infected mice compared with mice infected with the original isolate of T, pseudospiralis or with Trichi nella spiralis. Diaphragm muscle inflammation was greater in T. spiral is-infected than in mice infected with either isolate of T. pseudospir alis or concurrently infected with T. spiralis and either of the isola tes of T. pseudospiralis. Granuloma inflammation was lower in mice inf ected with either isolate of T. pseudospiralis compared with uninfecte d or T. spirialis-infected mice. The devil isolate down-regulated infl ammation more profoundly during the intestinal phase than the muscle p hase compared to the original isolate, differences which may be relate d to the biology of their natural hosts. (C) 1998 Australian Society f or Parasitology. Published by Elsevier Science Ltd.