FROM STYRENES TO ENANTIOPURE ALPHA-ARYLGLYCINES IN 2 STEPS

Citation
Kl. Reddy et Kb. Sharpless, FROM STYRENES TO ENANTIOPURE ALPHA-ARYLGLYCINES IN 2 STEPS, Journal of the American Chemical Society, 120(6), 1998, pp. 1207-1217
Citations number
31
Categorie Soggetti
Chemistry
ISSN journal
00027863
Volume
120
Issue
6
Year of publication
1998
Pages
1207 - 1217
Database
ISI
SICI code
0002-7863(1998)120:6<1207:FSTEAI>2.0.ZU;2-8
Abstract
Direct enantioselective synthesis of (R)- and (S)-N-Cbz- or N-BOC-prot ected alpha-arylglycinols from styrenes via catalytic asymmetric amino hydroxylation, with enantioselectivities up to 99% and isolated yields up to 80%, is described. In a subsequent oxidation step, these glycin ols yield the corresponding carbamate-protected alpha-arylglycines.