Kl. Reddy et Kb. Sharpless, FROM STYRENES TO ENANTIOPURE ALPHA-ARYLGLYCINES IN 2 STEPS, Journal of the American Chemical Society, 120(6), 1998, pp. 1207-1217
Direct enantioselective synthesis of (R)- and (S)-N-Cbz- or N-BOC-prot
ected alpha-arylglycinols from styrenes via catalytic asymmetric amino
hydroxylation, with enantioselectivities up to 99% and isolated yields
up to 80%, is described. In a subsequent oxidation step, these glycin
ols yield the corresponding carbamate-protected alpha-arylglycines.