H. Chowdhury et al., SYNTHESIS AND INSECT GROWTH-REGULATORY ACTIVITY OF ALKOXY-SUBSTITUTEDBENZALDOXIME ETHERS, Journal of agricultural and food chemistry, 46(2), 1998, pp. 731-736
Alkoxy-substituted benzaldoxime ethers, namely (i) 3-methoxy-4-ethoxyb
enzaldoxime N-O-alkyl ethers, (ii) 3,4-dimethoxybenzaldoxime N-O-alkyl
ethers, and (iii) 3,4-methylenedioxybenzaldoxime N-O-alkyl ethers, ha
ve been synthesized and evaluated for their insect growth regulatory a
ctivity against fifth-instar nymphs of the desert locust Schistocerca
gregaria F. When injected into insect hemolymph at the lowest dose lev
el of 3 mu g/nymph, 3,4-methylenedioxybenzaldoxime N-O-methyl ether an
d 3,4-methylenedioxybenzaldoxime N-O-isopropyl ether showed 40 and 50%
growth deformities respectively. On topical application (at 20 mu g/n
ymph) 3-methoxy-4-ethoxybenzaldoxime N-O-methyl ether inflicted 100% a
bnormalities in insect growth. Structure-activity relationship studies
revealed that maximum activity was associated with compounds having t
hree carbons in the oxime ether moiety.