COMPLEMENTARY-DNA (CDNA) SEQUENCE OF BABOON TUMOR-NECROSIS-FACTOR-ALPHA

Authors
HAUDEK SB REDL H SCHLAG G GIROIR BP
Citation
Sb. Haudek et al., COMPLEMENTARY-DNA (CDNA) SEQUENCE OF BABOON TUMOR-NECROSIS-FACTOR-ALPHA, Molecular immunology, 34(14), 1997, pp. 1041-1042
Citations number
6
Categorie Soggetti
Immunology,Biology
Journal title
Molecular immunology → ACNP
ISSN journal
01615890
Volume
34
Issue
14
Year of publication
1997
Pages
1041 - 1042
Database
ISI
SICI code
0161-5890(1997)34:14<1041:C(SOBT>2.0.ZU;2-R
Abstract
Baboons are less LPS-sensitive than humans, even though their immune r esponse mechanisms are similar. Since TNF alpha is a central mediator of the LPS-response we cloned and sequenced the baboon TNF alpha cDNA and compared the resulting sequence with the human TNF alpha sequence. Analysis of the TNF alpha protein coding region indicated 97% homolog y and of the 3' UTF 89%. The predicted baboon TNF alpha amino acid seq uence differed at 10 positions from the human sequence. ''TA'' rich mo tifs within the 3' UTR were 100% homologous. (C) 1997 Elsevier Science Ltd. All rights reserved.