LIPO-MICRODIALYSIS - A NEW MICRODIALYSIS METHOD FOR STUDYING THE PHARMACOKINETICS OF LIPOPHILIC SUBSTANCES

A new microdialysis method (Lipo-MD) using a lipid emulsion as the per fusate instead of Ringer's solution as in conventional microdialysis ( MD) was designed. Recovery profiles of the alkylparabens (APBs) dissol ved in Ringer's solution by Lipo-MD were compared with those by MD in vitro. Recovery of APBs in the perfusate in MD decreased with the incr easing lipophilicity of APBs, whereas that in Lipo-MD increased. The e nhancement of the relative recovery of APBs by Lipo-MD to MD for methy l-, ethyl-, propyl-, and butylparaben were 2.03, 5.24, 77.0, and 390.7 , respectively. The utility of Lipo-MD for determination of lipophilic substances to perform pharmacokinetic study was suggested.