PURPOSE: To evaluate the effect of reducing image size on observers' a
bility to detect lung nodules on computed tomographic (CT) scans. MATE
RIALS AND METHODS: Stimuli were 80 single sections from 13 normal ches
t CT studies. On half of the images, 3-5-mm-diameter nodules were supe
rimposed electronically at random locations. Four observed viewed imag
es in six formats and sizes that ranged from 6 on 1 (133 x 133 mm) to
80 on 1 (40 x 40 mm). The images were viewed at a fixed distance of 55
cm and at an unrestricted, variable distance. RESULTS: With the fixed
viewing distance, nodule detection decreased with smaller images size
s. The area under the receiver operating characteristic curve (A) decr
eased fro 0.857 for the 6-on-1 format to 0.671 for the 80-on-1 format
(P = .0001). With a variable viewing distance, A(2) decreased from 0.8
84 to 0.834 across all formats (difference not statistically significa
nt). However, there was a significant drop in performance with the sma
llest images (P < .05). Overall, A(2) for the fixed and variable viewi
ng distances was significantly different (P < .001). CONCLUSION: Reduc
ing image size leads to decreased lung nodule detection on CT scans vi
ewed at a fixed distance; however, the observer can compensate for the
smaller image by adjusting the viewing distance.