PURPOSE: To determine whether complete percutaneous removal of a malig
nant lesion detected at mammography ensures complete excision of the c
arcinoma histopathologically. MATERIALS AND METHODS: A retrospective r
eview was performed of 135 lesions in which stereotactic biopsy was pe
rformed with a directional, vacuum biopsy instrument and an 11-gauge p
robe followed by mammography. Carcinoma was diagnosed at stereotactic
biopsy in 51 (38%) lesions. In 15 (29%) carcinomas, the lesion seen at
mammography was removed at stereotactic biopsy. Surgical findings wer
e available for correlation with biopsy and imaging findings in all 15
cases. Mammographic and histopathologic findings were reviewed. RESUL
TS: Mammographic findings were calcifications in 11 lesions and a mass
in four lesions. The median lesion size was 0.7 cm (range, 0.2-1.4 cm
), and the median number of biopsy specimens was 15 (range, 10-22 spec
imens). Histopathologic findings at stereotactic biopsy were ductal ca
rcinoma in situ in 12 lesions and infiltrating ductal carcinoma in thr
ee. Surgery revealed residual carcinoma in 11 (73%) of 15 lesions, inc
luding all three infiltrating ductal carcinomas and eight of 12 ductal
carcinoma in situ lesions. CONCLUSION: Complete removal of the mammog
raphic lesion does not ensure complete excision of the carcinoma.