EFFECTS OF METALLIC ANTIOXIDANTS ON CADMIUM-CATALYZED PEROXIDATION OFARACHIDONIC-ACID

In the present study, the reaction mixtures (cadmium chloride with ara chidonic acid) were preincubated at 37 degrees C for 24 h prior to the measurement of malondialdehyde (MDA) by high performance liquid chrom atography (HPLC). The cadmium-catalyzed reactions were also compared t o those in the presence of selenium (Se), zinc (Zn) or germanium (Ge), metallic antioxidants. Our results showed that the toxic effects of c admium cause lipid peroxidation of arachidonic acid by the catalytic p rocess. The addition of metallic antioxidants to the reaction mixtures , might be useful in protecting against Cd-induced lipid peroxidation.