CYCLIC VOLTAMMETRY AND ELECTRON-PARAMAGNETIC-RESONANCE STUDIES OF SOME ANALOGS OF NIFURTIMOX

The EPR of radicals obtained by electrolytic reduction of some new ana logues of the antiprotozoal drug nifurtimox were measured in DMSO and DMF. The electrochemistry of these compounds was studied using cyclic voltammetry. AMI and INDO semiempirical molecular orbital calculations were performed to obtain the optimized geometries and spin distributi on, respectively. Density functional theory was used to rationalize th e reduction potentials of these compounds.