CD4(-CELL MEMORY, CD45R SUBSETS AND THE PERSISTENCE OF ANTIGEN - A UNIFYING CONCEPT() T)

Authors
BELL EB SPARSHOTT SM BUNCE C
Citation
Eb. Bell et al., CD4(-CELL MEMORY, CD45R SUBSETS AND THE PERSISTENCE OF ANTIGEN - A UNIFYING CONCEPT() T), Immunology today, 19(2), 1998, pp. 60-64
Citations number
50
Categorie Soggetti
Immunology
Journal title
Immunology today → ACNP
ISSN journal
01675699
Volume
19
Issue
2
Year of publication
1998
Pages
60 - 64
Database
ISI
SICI code
0167-5699(1998)19:2<60:CMCSAT>2.0.ZU;2-F
Abstract
The cellular basis of immunological memory has been reassessed in the light of recent evidence identifying two types of CD4(+) memory T cell . Here, Eric Bell and colleagues argue that two crucial components of memory - rapid recall and long life - belong not to one but to two dis tinct subsets of CD4(+) memory T cells: the CD45R(lo) and CD45R(hi) su bsets, respectively. Importantly, only the CD45R(lo) subset depends on persisting antigen.