INTERLEUKIN-15 - A PROINFLAMMATORY ROLE IN RHEUMATOID-ARTHRITIS SYNOVITIS

Authors
MCINNES IB LIEW FY
Citation
Ib. Mcinnes et Fy. Liew, INTERLEUKIN-15 - A PROINFLAMMATORY ROLE IN RHEUMATOID-ARTHRITIS SYNOVITIS, Immunology today, 19(2), 1998, pp. 75-79
Citations number
32
Categorie Soggetti
Immunology
Journal title
Immunology today → ACNP
ISSN journal
01675699
Volume
19
Issue
2
Year of publication
1998
Pages
75 - 79
Database
ISI
SICI code
0167-5699(1998)19:2<75:I-APRI>2.0.ZU;2-N
Abstract
In rheumatoid arthritis (RA), locally produced interleukin 15 (IL-15) can recruit and activate synovial T cells, which then amplify and perp etuate inflammation through induction of monocyte-derived tumour necro sis factor alpha (TNF-alpha) via a cell-contact-dependent mechanism. T hus, IL-15 could play a pivotal role in disease pathogenesis, acting u pstream of TNF-alpha in orchestrating the induction of a cascade of in flammatory cytokines.