A rare case of myoepithelial hamartoma of the duodenal wall is present
ed, and previous case reports found in the literature are reviewed. My
oepithelial hamartomas are thought to arise from displaced pancreatic
anlage present along the gastrointestinal tract during embryogenesis,
which can differentiate into various pancreatic elements; the most hig
hly differentiated form is heterotopic pancreas. An alternative theory
is pancreatic metaplasia of endodermal tissues. We describe a 41-year
-old man who presented with abdominal pain and vomiting. CT scanning r
evealed a mass at the head of the pancreas. A pancreaticoduodenectomy
was performed for presumed cystadenoma. Histology of the mass revealed
a disorderly arrangement of smooth muscle, dilated and nondilated duc
ts, pancreatic acinar tissue and mucus glands. The relationship of myo
epithelial hamartomas involving the small bowel to similar lesions in
the stomach, bile ducts and gallbladder is discussed.