IS THE MOLTEN GLOBULE A 3RD PHASE OF PROTEINS

Authors
PANDE VS ROKHSAR DS
Citation
Vs. Pande et Ds. Rokhsar, IS THE MOLTEN GLOBULE A 3RD PHASE OF PROTEINS, Proceedings of the National Academy of Sciences of the United Statesof America, 95(4), 1998, pp. 1490-1494
Citations number
35
Categorie Soggetti
Multidisciplinary Sciences
Journal title
Proceedings of the National Academy of Sciences of the United Statesof America → ACNP
ISSN journal
00278424
Volume
95
Issue
4
Year of publication
1998
Pages
1490 - 1494
Database
ISI
SICI code
0027-8424(1998)95:4<1490:ITMGA3>2.0.ZU;2-1
Abstract
The equilibrium properties of proteins are studied by Monte Carlo simu lation of two simplified models of protein-like heteropolymers. These models emphasize the polymeric entropy of the fluctuating polypeptide chain, Our calculations suggest a generic phase diagram that contains a thermodynamically distinct ''molten globule'' state in addition to a rigid native state and a nontrivial unfolded state. The roles of side -chain packing and loop entropy are discussed.