SYNTHESIS, CHEMICAL AND PHARMACOLOGICAL PROPERTIES OF SOME YL-1,2,3,4,5,6,7,8-OCTAHYDROQUINAZOLINE-2,5-DIONES

Authors
SARAC S YARIM M ERTAN M BOYDAG S EROL K
Citation
S. Sarac et al., SYNTHESIS, CHEMICAL AND PHARMACOLOGICAL PROPERTIES OF SOME YL-1,2,3,4,5,6,7,8-OCTAHYDROQUINAZOLINE-2,5-DIONES, Die Pharmazie, 53(2), 1998, pp. 91-94
Citations number
21
Categorie Soggetti
Pharmacology & Pharmacy","Chemistry Medicinal
Journal title
Die Pharmazie → ACNP
ISSN journal
00317144
Volume
53
Issue
2
Year of publication
1998
Pages
91 - 94
Database
ISI
SICI code
0031-7144(1998)53:2<91:SCAPPO>2.0.ZU;2-J
Abstract
A series of yl-1,2,3,4,5,6,7,8-octahydroquinazoline-2,5-diones were sy nthesized by condensing urea with 1,3-cyclohexanedione and appropriate aromatic aldehydes according to the Biginelli reaction. The structure s of the compounds were confirmed by elementary and spectroscopic anal ysis. The compounds synthesized were tested in vitro for their calcium antagonistic activities. BaCl2-induced contractions of rat ileum were inhibited dose-dependently. Compounds 3-8 exerted weak calcium antago nistic activity on smooth muscles compared with the standard nicardipi ne.