COMPATIBILITY OF CEFPIROME AND CEPHALOTHIN WITH PVC BAGS DURING SIMULATED INFUSION AND STORAGE

The stability and compatibility of cefpirome and cephalothin injection in 5% dextrose and 0.9% NaCl solutions with polyvinyl chloride contai ners were studied. A rapid isocratic technique was developed for the a nalysis of these drugs in parenteral solutions using a stability indic ating HPLC assay with UV detection and CII column. No significant drug loss was observed during the simulated infusions for 30 min and 1 h. The results show the stability of drugs during storage over 8 or 24 h at room temperature and 48 h at 4 degrees C to be satisfactory. In all cases during simulated infusions and storage, no di-ethyl-hexyl-phtha late was detected in cefpirome and cephalothin solutions.