EFFECTS OF EXTRACT OF OYSTER ON LIPID-METABOLISM IN RATS

We examined the effects of oyster (Ostrea en gingas Thunb.) water extr acts on hyperlipemia and liver injury produced in rats by feeding on p eroxidized oil. The extracts of oyster were found to reduce the levels of serum free fatty acid, triglyceride, lipid peroxide and liver chol esterol in the peroxidized oil-treated rats. In addition, we found tha t the water extracts of oyster inhibited adrenaline-induced lipolysis, and that these extracts stimulated lipogensis from glucose in isolate d fat cells of rats. The active substance was isolated and identified as adenosine by direct comparison with an authentic sample. (C) 1998 E lsevier Science Ireland Ltd.