PROLIFERATIVE ACTIVITY IN PERIPHERAL OSSIFYING FIBROMA AND OSSIFYING FIBROMA

A proliferative activity study analysing morphometric and quantitative aspects of nucleolar organizer regions (NORs) and proliferating cell nuclear antigen (PCNA) expression was conducted in 10 cases of periphe ral ossifying fibroma (POF) and 10 cases of ossifying fibroma (OF). Fo r NOR identification, the silver staining technique (AgNOR technique) was used. PCNA expression was determined by immunohistochemical staini ng using the PC10 antibody. The AgNOR analysis for the two lesions sho wed a profile characteristic of benign lesions. OF showed higher AgNOR number and PCNA expression than POF. Our results suggest increased pr oliferative activity in OF compared with POF.