OXIDATIVE STRESS AND ENZYME-ACTIVITY IN AMBULATORY RENAL PATIENTS UNDERGOING CONTINUOUS PERITONEAL-DIALYSIS

Some parameters indicating the possibility of oxidative stress in chro nic renal failure patients (CRF) undergoing continuous ambulatory peri toneal dialysis (CAPD), are presented in this study. Oxidative stress appears to be lower than in hemodialysis patients. In a group of CRF p atients and in a control group malondialdehyde (MDA) was determined as an indicator of red-blood-cell membrane lipid peroxidation. Also, the three glutathione forms, total (GST), oxidated (GSSG) and reduced (GS H) and the levels of glutathione peroxidase (GPX), the levels of the a ntioxidant enzymes superoxide dismutase (SOD) and catalase (CAT) have been measured. Significantly higher MDA values (p <.05) have been foun d in CRF patients when compared to controls. The three forms of glutat hione and GPX are also significantly decreased in the CRF group (p <.0 5 and p <.001, respectively). The levels of SOD and CAT are increased with respect to the control group (p <.001).