DEVELOPMENT OF A METHOD FOR THE SYSTEMATIC USE OF BILINEAR MULTIVARIATE CALIBRATION METHODS FOR THE CORRECTION OF INTERFERENCES IN INDUCTIVELY-COUPLED PLASMA-MASS SPECTROMETRY

The multivariate bilinear calibration methods Principal Component Regr ession (PCR) and Partial Least Squares Regression (PLS) are investigat ed for their capability to correct interferences in ICP-MS analysis. A universally applicable method is developed by optimizing the paramete rs for experimental design, for data pretreatment by internal standard isation, scaling, and mean centering, for the determination of the opt imal number of latent variables, and for variable selection. Validatio n is performed with an artificial test system containing a wide range of representative analytes and interferences. (C) 1998 Elsevier Scienc e B.V.