STUDIES ON THE ADSORPTIVE BEHAVIOR OF MAZINDOL AND ITS ADSORPTIVE STRIPPING VOLTAMMETRY

A sensitive reduction peak of mazindol is obtained by adsorptive strip ping voltammetry in 0.1 M H2SO4 at an accumulation time of 180 s. The peak potential is -0.72 V (vs. Ag/AgCl). The peak current is directly proportional to the concentration of mazindol (1x10(-8)-8x10(-7) M), w ith a 3 sigma detection limit of 4.0x10(-9) M. The behaviour of the re duction wave has been studied and applied to the determination of mazi ndol in tablets. The reduction process is irreversible with adsorptive characteristics. Its behaviour obeys a Frumkin adsorption isotherm. T he adsorption coefficient beta is 8.91x10(5) l mol(-1) and the interac tion factor alpha is 0.22. The mechanism of the electrode reduction is discussed. (C) 1998 Elsevier Science B.V.