SILICONE GRANULOMAS - 30 YEARS AFTER INJECTION OF FLUID SILICONE FOR BREAST AND INNER THIGH AUGMENTATION - A POSSIBLE CASE OF HUMAN ADJUVANT DISEASE IMPROVED AFTER MASSIVE SILICONOMAS REMOVAL

Besides the list of six characteristics of the so called ''Human Adjuv ant Disease'' (HAD) described by Miyoshi in 1964 [13] a major obstacle to the general recognition of HAD has been the varying definitions of the disorder [1]. In the original and most complete paper on the clin ical findings of connective tissue disease after injection of foreign substances, published by Kumagai [11] in 1984, 18 patients were report ed on and a review of 28 additional cases from the Japanese literature was presented. The patients were classified into 2 major groups: grou p I consisted of 24 patients with definite connective tissue disease a nd group II consisted of 22 patients with HAD with some symptoms, sign s and laboratory findings suggestive but not diagnostic of any specifi c connective tissue disease. The patient described in this paper had c linical features comparable to a similar case described by Sergott [20 ] in 1986. The diagnosis was silicone mastitis and a possibly human ad juvant disease.