Although pyoctanin is widely used in medicine, there are hardly any re
ports of contact allergy to it. Most reports of side-effects refer to
irritant reactions after topical application. We describe 2 patients w
ho developed pyoctanin contact dermatitis after long-term application
on damaged skin. Positive patch test results down to concentrations of
0.0025% and 0.05% aqueous pyoctanin solution, respectively, were foun
d.