OXIDATIVE AND RANDOM CLEAVAGE OF DNA BY THE NOVEL IRON(II) COMPLEX CAPABLE OF YIELDING AN IRON(III) HYDROPEROXIDE INTERMEDIATE

Authors
ISHIKAWA Y MORISHITA Y YAMAMOTO T KUROSAKI H GOTO M MATSUO H SUGIYAMA M
Citation
Y. Ishikawa et al., OXIDATIVE AND RANDOM CLEAVAGE OF DNA BY THE NOVEL IRON(II) COMPLEX CAPABLE OF YIELDING AN IRON(III) HYDROPEROXIDE INTERMEDIATE, Chemistry Letters, (1), 1998, pp. 39-40
Citations number
17
Categorie Soggetti
Chemistry
Journal title
Chemistry Letters → ACNP
ISSN journal
03667022
Issue
1
Year of publication
1998
Pages
39 - 40
Database
ISI
SICI code
0366-7022(1998):1<39:OARCOD>2.0.ZU;2-W
Abstract
A novel Fe(II) complex and H2O2 system causes sequence non-specific do uble-strand breaks of duplex DNAs at micromolar concentrations and the DNA cleavage is independent of tile presence of hydroxyl radical scav engers. The same system can also oxidize hydrocarbons and the active s pecies in the system is likely to be a Fe(III) hydroperoxide complex s upported by characteristic purple absorption and EPR signals.