Compliance with medical advice has always been a problem and there has
always been discussion on who is to blame for noncompliance: the illn
ess, the physician, the patient or the drug? A consensus between the p
hysician's beliefs, views and representations of the nature and the et
iology of the depression and of the treatment options on the one hand
and the patient with his individual life story on the other is probabl
y the best guarantee of reasonable compliance. In particular, a physic
ian-patient consensus about the emotional meaning of the illness is es
sential: patients should be given the opportunity to express their fee
lings about the illness and what it signifies, and physicians should r
espond with feedback using the patient's concepts and emotional expres
sion. Within this context of dialogue, patients may signal their resis
tance to and potential noncompliance with the physician's views. An em
pathic model of understanding can be used in the initial stages of the
consultation. Finding an equilibrium between the cognitive-informatio
nal aspects of depressive illness and treatment on one hand and affect
ive-motivational aspects on the other is a key factor in antidepressiv
e treatment. Physicians should indeed always try to overcome the gap b
etween the affective (empathy, motivational aspects) and the instrumen
tal dimensions (correct diagnosis, adequate treatment) of their behavi
or. (C) 1998 Rapid Science Ltd.