PEROXIDATION STATUS OF ERYTHROCYTES AND APOLIPOPROTEIN-B CONTAINING LIPOPROTEINS IN HYPERCHOLESTEROLEMIC SUBJECTS

Erythrocyte diene conjugate levels and glutathione peroxidase and supe roxide dismutase activities were found unchanged in hypercholesterolem ic subjects with plasma cholesterol levels above 240 mg/dl as compared to normocholesterolemics (below 200 mg/dl). However, the susceptibili ty of VLDL + LDL, apolipoprotein B containing lipoproteins to copper-i nduced peroxidation and plasma endogenous malondialdehyde levels were increased in hypercholesterolemics. These results indicate that hyperc holesterolemia is associated with increased susceptibility of VLDL + L DL to lipid peroxidation.