OBJECTIVE - Staged diabetes management should permit glycemic goals to
be attained in a timely manner, but the success of such an approach r
equires conformity by health care providers. To lest performance, we a
nalyzed the adherence of practitioners to a protocol for staged manage
ment of NIDDM patients. RESEARCH DESIGN AND METHODS - Records of patie
nts treated at the Grady Memorial Hospital Diabetes Clinic were review
ed retrospectively over a 3-year period. For each patient, intensifica
tion of therapy was indicated if fasting plasma glucose was >7.8 mmol/
l and a prior HbA(1c) was >7.0%. Protocols dictated a progression from
dietary therapy alone to increasing dosages of sulfonylureas to incre
asing dosages of insulin. Patients were seen at bimonthly intervals. R
ESULTS - During the 3-year period, 1,051 patient visits met protocol c
riteria for intensification. Adherence to the protocol improved signif
icantly in the 3rd year compared with the first 2 years (30, 31, and 4
7% adherence in the 1st, 2nd, and 3rd years, respectively). Patients t
reated with diet alone were significantly less likely to have their th
erapy intensified than patients on sulfonylureas or insulin (intensifi
cation rates 25, 41, and 47%, respectively). In the management of pati
ents treated with diet alone, practitioners were reluctant to intensif
y therapy at early visits, but were more likely to do so later; 19% of
patients beyond goal range at the 2-month visit were started on pharm
acological therapy vs. 28% at the 4-month visit, and 39% at the 6-mont
h visit (P < 0.01). In contrast, there was no significant difference i
n the frequency of therapy intensification between early and late visi
ts for patients on sulfonylureas or insulin. Practitioners appeared to
base the decision to intensify on the fasting plasma glucose level mo
re than on the most recent HbA(1c). Age did not appear to be a signifi
cant factor in the decision to intensify. CONCLUSIONS - Although stage
d management protocols constitute critical tools to achieve glycemic g
oals, the adherence of health care providers may be suboptimal. Specia
l efforts may be needed to assure compliance.