SPECTROPHOTOMETRIC DETERMINATION OF SILVERSULFADIAZINE IN PHARMACEUTICAL DOSAGE FORMS

A method for determining silver in silver sulfadiazine pharmaceutical creams and ointments has been developed. Organic residues in the produ cts are destroyed with sulfuric acid and nitric acid mixture. After ev aporation of acids the silver is reduced with formaldehyde in alkaline solution, pH 11 - 12.5, to the metallic state; which is then reoxidiz ed at pH 3.5 with iron(III) in the presence of ferrozine. The resultin g absorbance is measured at 562 nm. Average recoveries of 99.7 +/- 0.1 9 % and 99.6 +/- 0.12 % are obtained for the two pharmaceutical prepar ations tested, respectively.