Progress in the development of drug targeting technologies is advancin
g at an ever-increasing rate as we hurtle toward the new millennium. E
xamination of just the past three years of the drug delivery technolog
y patent literature suggests that what was previously thought impossib
le may now be a reality. As one goes through this literature, the brea
dth and ingenuity of many of these approaches are obvious. As ill the
inaugural article, I have grouped information gathered from this searc
h into areas of mucosal targeting, organ and/or tissue targeting, tumo
r targeting and focal delivery. The patent applications described in t
his article represent a sampling of the work in these areas, with part
icular attention being paid to a few of the more novel or intriguing c
laims.