IMMUNOSUPPRESSANT ACTIVITY IN HUMAN BETA-CASEIN FRAGMENT ANALOGS

Authors
BHATTACHARYA M PURI A SAHAI R HAQ W TRIPATHI LM SRIVASTAVA VML
Citation
M. Bhattacharya et al., IMMUNOSUPPRESSANT ACTIVITY IN HUMAN BETA-CASEIN FRAGMENT ANALOGS, Bioorganic & medicinal chemistry letters, 8(4), 1998, pp. 327-332
Citations number
12
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
8
Issue
4
Year of publication
1998
Pages
327 - 332
Database
ISI
SICI code
0960-894X(1998)8:4<327:IAIHBF>2.0.ZU;2-O
Abstract
Human beta-casein fragment (54-59) having the amino acid sequence Val- Glu-Pro-Ile-Pro-Tyr, has been shown potent immunostimulant activity. S everal analogs of this hexapeptide have been synthesized with modifica tion in the N-terminal region and tested for their immunomodulatory ac tivity. Intrestingly, two hexapeptides have shown significant immunosu ppressant activity. (C) 1998 Elsevier Science Ltd. All rights reserved .