POTENT AND SELECTIVE INHIBITORS OF THE PROTEASOME - DIPEPTIDYL BORONIC ACIDS

Authors
ADAMS J BEHNKE M CHEN SW CRUICKSHANK AA DICK LR GRENIER L KLUNDER JM MA YT PLAMONDON L STEIN RL
Citation
J. Adams et al., POTENT AND SELECTIVE INHIBITORS OF THE PROTEASOME - DIPEPTIDYL BORONIC ACIDS, Bioorganic & medicinal chemistry letters, 8(4), 1998, pp. 333-338
Citations number
24
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
8
Issue
4
Year of publication
1998
Pages
333 - 338
Database
ISI
SICI code
0960-894X(1998)8:4<333:PASIOT>2.0.ZU;2-O
Abstract
Potent and selective dipeptidyl boronic acid proteasome inhibitors are described. As compared to peptidyl aldehyde compounds, boronic acids in this series display dramatically enhanced potency. Compounds such a s 15 are promising new therapeutics for treatment of cancer and inflam matory diseases. (C) 1998 Elsevier Science Ltd. All rights reserved.