SYNTHESIS OF ALPHA-ARYL N-ADAMANT-1-YL NITRONES AND USING THEM FOR SPIN-TRAPPING OF HYDROXYL RADICALS

Authors
SAR CP HIDEG E VASS I HIDEG K
Citation
Cp. Sar et al., SYNTHESIS OF ALPHA-ARYL N-ADAMANT-1-YL NITRONES AND USING THEM FOR SPIN-TRAPPING OF HYDROXYL RADICALS, Bioorganic & medicinal chemistry letters, 8(4), 1998, pp. 379-384
Citations number
19
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
8
Issue
4
Year of publication
1998
Pages
379 - 384
Database
ISI
SICI code
0960-894X(1998)8:4<379:SOANNA>2.0.ZU;2-M
Abstract
alpha-Aryl N-adamant-1-yl nitrones were synthesized and evaluated with respect to the stability of the hydroxyl radical adduct. The polarity and water solubility of nitrones were altered with changing the alpha -aryl groups. Introduction of adamantane ring instead of tert-butyl gr oup resulted in a reasonable good stability of hydroxyl radical adduct for biological measurements. (C) 1998 Elsevier Science Ltd. All right s reserved.