Objectives. To describe surgical options that may be indicated when co
nservative management of overactive bladder is unsuccessful. Methods.
The literature on current endoscopic and open surgical procedures is r
eviewed. Results. The endoscopic approach of hydrodistention under ane
sthesia may be therapeutic, but normally offers only temporary relief
of symptoms. Among open surgical procedures, cystolysis has not withst
ood the test of time and is no longer used. Partial rhizotomy can redu
ce reflex bladder contractility while preserving other important uroge
nital functions. Peripheral denervation via a vaginal approach appears
effective in as many as 70% of patients with motor instability, but i
s not effective in interstitial cystitis or other sensory bladder diso
rders. Transvesical phenol injection is most effective for detrusor in
stability (DI) caused by multiple sclerosis. Enterocystoplasty is more
helpful in intractable DI than in interstitial cystitis. Detrusor myo
mectomy has yielded excellent results in patients with neurogenic caus
es of DI. Urinary diversion is rarely required in DI, but may be prefe
rable to enterocystoplasty when severe pelvic pain is present. Conclus
ions. When appropriately chosen, surgical procedures can substantially
improve the quality of life of some individuals with overactive bladd
er. (C) 1998, Elsevier Science Inc. All rights reserved.