SYNTHESIS OF NEW TETRAKIS N-SUBSTITUTED TETRA-AZAMACROCYCLES

The synthesis of new tetra-kis N-substituted tetra-azamacrocyles was a chieved. In the case of tetra amido analogues the best yields were obt ained through the use of Schotten-Bauman reaction type in a biphasic s ystem. In the case of tetra-N-omega alkyl carboxylic esters, optimal e xperimental conditions leading to the desired tetra N-substituted deri vatives are described.