OPTIMIZATION OF A REGRESSION-MODEL FOR A QUANTITATIVE STRUCTURE - MUTAGENICITY RELATIONSHIP OF SOME NATURAL AMINO-ACIDS

Authors
KUANAR M MISHRA BK
Citation
M. Kuanar et Bk. Mishra, OPTIMIZATION OF A REGRESSION-MODEL FOR A QUANTITATIVE STRUCTURE - MUTAGENICITY RELATIONSHIP OF SOME NATURAL AMINO-ACIDS, Bulletin of the Chemical Society of Japan, 71(1), 1998, pp. 191-198
Citations number
43
Categorie Soggetti
Chemistry
Journal title
Bulletin of the Chemical Society of Japan → ACNP
ISSN journal
00092673
Volume
71
Issue
1
Year of publication
1998
Pages
191 - 198
Database
ISI
SICI code
0009-2673(1998)71:1<191:OOARFA>2.0.ZU;2-R
Abstract
Multivariate statistical tools, such as principal-component analysis a nd multiple-regression analysis, were used for a large number of struc tural and empirical parameters of some eleven natural amino acids for predicting mutagenicity. An optimized regression model was derived fro m some selective principal components and solubility data. Plots relat ed to the principal components resulted in the ordination of amino aci ds as well as the structural and empirical parameters.