Wb. Shelley et Ed. Shelley, AQUADYNIA - NORADRENERGIC PAIN INDUCED BY BATHING AND RESPONSIVE TO CLONIDINE, Journal of the American Academy of Dermatology, 38(2), 1998, pp. 357-358
We describe two women in whom bathing was regularly followed by intens
e, widespread burning pain that lasted 15 to 45 minutes, which we term
aquadynia. This water-induced pain was not caused by any skin or syst
emic diseases. We view it as a type of noradrenergic pain induced by c
ontact with water, because it can be blocked with clonidine or propran
olol. It appears to be an extension of the phenomenon of aquagenic pru
ritus, which we have also found to respond to clonidine or propranolol
.