SURVIVAL AFTER HIGH-DOSE INTRAPERITONEAL INFUSION OF GLYCINE SOLUTIONIN THE MOUSE

We used an animal model to study whether glycine prompts death after a bsorption of irrigating fluid by the extravascular route. Mice were di vided into groups of 10 and given an intraperitoneal infusion of 200, 225, 250, 275 or 300 ml/kg of glycine 1.1%, 1.5% or 2.2%. With all inf used volumes, the chance of survival was better after infusion of glyc ine 1.1% and glycine 1.5% than after glycine 2.2%. The overall death r ates were 10%, 16% and 46%, respectively. Logistic regression analysis showed that the outcome was significantly and independently affected by both the glycine concentration and the infused volume. We conclude that the glycine concentration of an irrigating fluid deposited in the peritoneal cavity is important to the chance of survival. The poorest chance is obtained with glycine 2.2%.