TRANSITIONAL-CELL CARCINOMA EXPRESS VITAMIN-D RECEPTORS

Recently, vitamin D analogues have shown antineoplastic effect in seve ral diseases. Vitamin D analogues exert its effect by interacting with the vitamin D receptor (VDR). Studies of VDR in transitional cell car cinoma (TCC) have not been reported. The purpose of the present study was therefore to examine whether human bladder tumor cells express VDR . Tumor biopsies were obtained from 26 patients with TCC. Expression o f VDR was examined by immunohistochemical experiments. All tumors expr essed VDR. Biopsies from advanced disease contained more VDR positive cells than low stage disease (p < 0.05). Similarly, also tumor grade a ppeared to be related to the number of cells expressing the receptor. Normal urothlium also expressed VDR but only with low intensity. Our s tudy shows that TCC cells possess the VDR receptor which may make them capable to respond to stimulation with vitamin D, but functional stud ies of vitamin D's effect on TCC cells in vitro are necessary before t he efficacy of treatment with vitamin D analogues in TCC can be evalua ted in patients.