CISAPRIDE ENHANCES DETRUSOR CONTRACTILITY AND IMPROVES MICTURITION INA WOMAN WITH LAZY BLADDER

A 32-year-old woman with lazy bladder was treated with cisapride (10 m g q.i.d.) for three weeks, obtaining a progressive improvement of the symptomatology and urodynamic parameters, and the return to pretreatme nt conditions after drug withdrawal. This case agrees with the evidenc e that cisapride potentiates the release of acetylcholine from postgan glionic cholinergic nerves in the human isolated detrusor by activatin g 5-HT4 receptors, i.e. through the same mechanism responsible for its gastrointestinal prokinetic action. It is concluded that selective 5- HT4 agonists could be potentially useful to improve bladder emptying i n micturition disorders associated with detrusor hypocontractility.