CHANGES IN VIROLOGICAL MARKERS AS PREDICTORS OF CD4 CELL DECLINE AND PROGRESSION OF DISEASE IN HUMAN-IMMUNODEFICIENCY-VIRUS TYPE 1-INFECTEDADULTS TREATED WITH NUCLEOSIDES

The associations of CD4 cell count, plasma human immunodeficiency viru s (HIV) type 1 RNA, infectious HIV titer in peripheral blood mononucle ar cells, immune complex-disrupted (ICD) p24 antigen, and MT-2 assays with measures of disease progression after drug treatment were assesse d in a subset of patients enrolled in AIDS Clinical Trials Group Study 175, Baseline plasma RNA levels and changes in RNA values at weeks 8 or 56 were more important predictors of disease progression than were baseline or changes in CD4 cell counts, Each 10-fold lower HIV RNA con centration at baseline and each 10-fold decrease in HIV RNA between ba seline and week 8 was associated with increases of 49-61 CD4 cells/mm( 3) at weeks 56 and 104, In multivariate analyses, neither baseline val ues nor changes in infectious HIV titer nor ICD p24 antigen concentrat ions were associated with long-term changes in CD4 cell count, Plasma HIV-1 RNA appears to be the best predictor of long-term CD4 cell count responses and disease progression.