Since its discovery almost 25 years ago the enigmatic hydrogenosome, a
redox organelle of anaerobic unicellular eukaryotes, has puzzled evol
utionists as to its origin and function. Synthesis of recent molecular
, physiological and morphological studies now favours the hypothesis t
hat hydrogenosomes derived from a modification of pre-existing mitocho
ndria, and argues against the previously held view that the hydrogenos
ome had a polyphyletic origin. These data provide evidence for a more
ancient origin of mitochondria than hitherto thought.