TOTAL ANTIOXIDANT STATUS, LIPID PARAMETERS, LIPID-PEROXIDATION AND GLUTATHIONE LEVELS IN PATIENTS WITH ACUTE MYOCARDIAL-INFARCTION

Free oxygen radicals and subsequent lipid peroxidation are considered to be responsible for coronary artery disease. We conducted this study to determine the blood paramenters concerning the oxidative process i n acute myocardial infarction. Plasma total antioxidant status (TAS), total cholesterol (TC), triglyceride (TG), high-density lipoproteins ( HDL-C), low-density lipoproteins (LDL-C) and thiobarbituric acid react ive substance ((TBARS) levels were examined as well as erythrocyte TBA RS and glutathione (GSH) in 20 patients with acute myocardial infarcti on (AMI) admitted to the Emergency Department in Instabul University, Istanbul Faculty of Medicine, and in healthy matched control subjects. As compared to healthy controls, plasma TBARS, T-C, TG and LDL-C leve ls were significantly elevated in patients with AMI (P < 0.01). There were significant associations between the HDL-C levels and TAS of pati ents and controls, positive correlations between erythrocyte GSH and T BARS, TC and LDL-C, TC and TG levels and a negative correlation betwee n TAS and plasma TBARS. We conclude that oxidative stress may play an important role in acute myocardial infarction. (C) 1998 Chapman & Hall Ltd.