A 3-DIMENSIONAL MODEL TO STUDY A COMBINAT ION OF 3 ANTIBIOTICS IN-VITRO - APPLICATION TO THE BACTERICIDAL ACTIVITY OF PIPERACILLIN, TAZOBACTAM AND AMIKACIN AGAINST 5 STRAINS OF ENTEROBACTERIA ACCORDING TO THEIR BETA-LACTAM RESISTANCE PATTERNS

Authors
DUEZ JM CORDIN X SIEBOR E PECHINOT A CHAMARDNEUWIRTH C KAZMIERCZAK A
Citation
Jm. Duez et al., A 3-DIMENSIONAL MODEL TO STUDY A COMBINAT ION OF 3 ANTIBIOTICS IN-VITRO - APPLICATION TO THE BACTERICIDAL ACTIVITY OF PIPERACILLIN, TAZOBACTAM AND AMIKACIN AGAINST 5 STRAINS OF ENTEROBACTERIA ACCORDING TO THEIR BETA-LACTAM RESISTANCE PATTERNS, Pathologie et biologie, 46(1), 1998, pp. 67-72
Citations number
21
Categorie Soggetti
Pathology
Journal title
Pathologie et biologie → ACNP
ISSN journal
03698114
Volume
46
Issue
1
Year of publication
1998
Pages
67 - 72
Database
ISI
SICI code
0369-8114(1998)46:1<67:A3MTSA>2.0.ZU;2-M
Abstract
We described an in vitro 3-dimensional model to study the bactericidal activity of piperacillin (P), tazobactam (T) and amikacin (A) in comb ination against 5 strains of enterobacteria with different resistance patterns to p-lactam antibiotics. A synergy was defined by calculation of Sigma FBCP,T,A = BCp/MBCp + BCT/MBCT + BCA/MBCA and classic Sigma FBCs for each double combination. The therapeutic value of each antibi otic was estimated by comparison of its bactericidal concentrations al one and in double or triple combination.