A 3-DIMENSIONAL MODEL TO STUDY A COMBINAT ION OF 3 ANTIBIOTICS IN-VITRO - APPLICATION TO THE BACTERICIDAL ACTIVITY OF PIPERACILLIN, TAZOBACTAM AND AMIKACIN AGAINST 5 STRAINS OF ENTEROBACTERIA ACCORDING TO THEIR BETA-LACTAM RESISTANCE PATTERNS
Jm. Duez et al., A 3-DIMENSIONAL MODEL TO STUDY A COMBINAT ION OF 3 ANTIBIOTICS IN-VITRO - APPLICATION TO THE BACTERICIDAL ACTIVITY OF PIPERACILLIN, TAZOBACTAM AND AMIKACIN AGAINST 5 STRAINS OF ENTEROBACTERIA ACCORDING TO THEIR BETA-LACTAM RESISTANCE PATTERNS, Pathologie et biologie, 46(1), 1998, pp. 67-72
We described an in vitro 3-dimensional model to study the bactericidal
activity of piperacillin (P), tazobactam (T) and amikacin (A) in comb
ination against 5 strains of enterobacteria with different resistance
patterns to p-lactam antibiotics. A synergy was defined by calculation
of Sigma FBCP,T,A = BCp/MBCp + BCT/MBCT + BCA/MBCA and classic Sigma
FBCs for each double combination. The therapeutic value of each antibi
otic was estimated by comparison of its bactericidal concentrations al
one and in double or triple combination.